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Unique evolutionary pathways during recurrence of different gliomas
Glioma recurrence has long plagued patients and neurosurgeons however with the development of molecular diagnosis of glioma, research recently published in the journal Nature, has become increasingly precise. A recent study by Mao Ying, President of Fudan University-affiliated Huashan Hospital and Director of TCCI Translational Center, and Professor Hua Wei from the Neurosurgery Department of […]
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Drug Delivery Platform Uses Sound for Targeting
Chemotherapy as a treatment for cancer is one of the major medical success stories of the 20th century, but it’s far from perfect. Anyone who has been through chemotherapy or who has had a friend or loved one go through it will be familiar with its many side effects: hair loss, nausea, weakened immune system, […]
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“Invisible” Cell Types and Gene Expression Revealed with Sequencing Data Analysis Improvement
In 2018, researchers in the Caltech laboratory of Yuki Oka, Chen Scholar, professor of biology and Heritage Medical Research Institute Investigator, made a major discovery: they identified a type of neuron, or brain cell, that mediates thirst satiation. But they were running into a problem: a state-of-the-art technique called single-cell RNA sequencing (scRNA-seq) could not […]
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Reconstructing Music from Human Auditory Cortex Activity Using Nonlinear Decoding Models
Music is core to the human experience yet the precise neural dynamics underlying music perception remain unknown. Dr. Gerwin Schalk, Director of the Chen Frontier Lab for Neurotechnology was part of a team of researchers who analyzed a unique intracranial electroencephalography (iEEG) dataset of 29 patients who listened to a Pink Floyd song and applied […]
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Huashan Hospital Maps Dementia Risk Factors; Active Interventions can Prevent 47%-73% of Dementia Cases
A study, recently published in the journal Nature Human Behavior (IF: 30) by the clinical research team of Prof. Yu Jintai from the Department of Neurology at Fudan University-affiliated Huashan Hospital, comprehensively mapped the modifiable risk factors for dementia for the first time. The research explored their joint effect on dementia and predicted that 47% […]
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Spatio-temporal evolution of human neural activity during visually cued hand movements
Making hand movements in response to visual cues is common in daily life. It has been well known that this process activates multiple areas in the brain, but how these neural activations progress across space and time remains largely unknown. Taking advantage of intracranial electroencephalographic (iEEG) recordings using depth and subdural electrodes from 36 human […]
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Unexpected sound omissions are signaled in human posterior superior temporal gyrus: an intracranial study
Our brains are excellent at making predictions about what we should hear next, based on context. These predictions help us understand and interact with our surroundings. For example, when listening to a melody, we may predict the next note in a sequence. Dr. Gerwin Schalk, Director of the Chen Frontier Lab for Applied Neurotechnology, and […]
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Scientists Create Embryo-Like Model that Mimics Post-Implantation Stage of Human Development
The human body and all its complexity arise from just a small collection of cells that divide and morph into different types of tissues. But exactly how this occurs is hard to study because embryos are hidden inside their mothers. Some embryos are donated to science by individuals who have undergone in vitro fertilization, but […]
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A Motor Association Area In The Depths Of The Central Sulcus
A specific part of the brain called the precentral gyrus is responsible for sending signals to the body’s muscles to make them move. Ever since the seminal work of Wilder Penfield close to 100 years ago, we have known that different areas of the precentral gyrus correspond to different parts of the body, like a […]
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A New Mechanism for Crossing the Blood–Brain Barrier
The blood–brain barrier (BBB) is a stringent, nearly impenetrable layer of cells that guards the brain, protecting the vital organ from hazards in the bloodstream such as toxins or bacteria and allowing only a very limited set of small molecules, such as nutrients, to pass through. This layer of protection, however, makes it difficult for […]