TCCI for Translational Research Director Heralds a New Era of Glioma Surgery with Pioneering Research

Dr. Mao Ying, President of Fudan University-affiliated Huashan Hospital and Director of the Tianqiao and Chrissy Chen Institute for Translational Research, along with his team, recently collaborated with Professor Wei Hua, Professor Zheng Ouyang from Department of Precision Instrument of Tsinghua University, Professor Graham Cooks from Purdue University and Professor Alfredo Quinones-Hinojosa from Mayo Clinic to develop a comprehensive intraoperative diagnostic procedure for detecting IDH mutations in gliomas, reducing the detection time to 1.5 minutes. This advancement helps surgeons to rapidly identify tumor types, balancing tumor resection rates with neurological function preservation, and determining surgical boundaries during operations. Their research findings are published in a paper titled “Rapid detection of IDH mutations in gliomas by intraoperative mass spectrometry” in the Proceedings of the National Academy of Sciences (PNAS).

The study achieved 100% accuracy in detecting IDH mutations in 697 samples from 260 glioma patients, a process that was notably more time-efficient compared to other methods. Furthermore, the diagnostic accuracy remained close to 100% in the operating room setting.

This study also validated the application of mass spectrometry in rapid intraoperative diagnosis, demonstrating its significant clinical value. It opens up possibilities for innovative advancements in various surgical procedures in the future.

Read the article on PNAS