TCCI Investigator Jintai Yu’s Team Reveals Distribution and Risk Factors of Alzheimer’s Disease Continuum in Northern Chinese Han Population

Recently, Jintai Yu, Professor at Fudan University-affiliated Huashan Hospital and Investigator at Tianqiao and Chrissy Chen Institute, published a paper titled Application of the Amyloid/Tau/Neurodegeneration Framework in Cognitively Intact Adults: The CABLE Study in the journal Annals of Neurology. The study aims to reveal the distribution and risk factors of Alzheimer’s Disease (AD) continuum in northern Chinese Han Population.


According to the research, approximately one-third of individuals (33.7%) belonged to the AD continuum. Four potential modifiable risk factors, including hypertension, thyroid diseases, social isolation, and minimal depression symptoms, were identified for the AD continuum. A trend toward a higher prevalence of the AD continuum was associated with a larger number of risk factors. The risk of AD continuum increased by approximately twofold for each additional modifiable risk factor. This study revealed the distribution and potential risk factors of the AD continuum in a cognitively intact Han population in northern China, which filled the gap in the area about the performance of the amyloid/tau/neurodegeneration (AT[N]) framework in the Asian population.


Read the paper