A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a hallmark of Alzheimer’s disease and several other neurodegenerative disorders.
Their findings may help to better understand the pathological process and possibly lead to developing medications to treat such devastating brain diseases.
The study, “Regulatory mechanisms of tau protein fibrillation under the conditions of liquid-liquid phase separation,” was published this week in the journal Proceedings of the National Academy of Sciences.