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Evolutionary and heritable axes shape our brain
Every region has its place in the brain. However, it has been unclear why brain regions are located where they are. Now, scientists at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) and the Forschungszentrum Jülich have defined two main axes along which brain regions are genetically organized, stretching from posterior […]
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TCCI® Director, Professor Ying Mao Introduces New Technologies for Epilepsy Treatment in a Paper Published in the Journal Nature, Biomedical Engineering
On September 28, Professor Ying Mao, Director of the Tianqiao and Chrissy Chen Institute for Translational Research, and Professor Cong Li from the School of Pharmacy at Fudan University, published a paper, titled ” An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy” in the journal Nature […]
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Nerve cells let others “listen in”
How many “listeners” a nerve cell has in the brain is strictly regulated. This is shown by an international study led by the University College London and the universities of Bonn, Bordeaux and Milton Keynes (England). In the environment of learning neurons, certain processes are set in motion that make signal transmission less exclusive. The […]
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Research challenges conventional wisdom about key autism trait
A new study into the causes of sensorimotor impairments prevalent among autistic people could pave the way for better treatment and management in the future, say psychologists. Publishing findings in the leading journal BRAIN [today: Friday 25 September], the scientists from the universities of Exeter and Bath present fresh evidence that sensorimotor difficulties associated with […]
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Anxious, moody older adults are vulnerable to worse cognitive function
Our aging brains collect tangles and sticky plaques that can interfere in our cognition and memory. But some older adults with this neuropathology have more cognitive resilience than others, reports a new Northwestern Medicine study.
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A Genetic Variant That Protects Against Alzheimer’s Promotes Immune Cell Functions
A new study conducted by researchers at the University of Eastern Finland found that the PLCG2-P522R genetic variant, which protects against Alzheimer’s disease, enhances several key functions of immune cells. The results obtained in the study highlight the importance of immune cells as a target of future development of new therapies for Alzheimer’s disease.
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Stem cells can repair Parkinson’s-damaged circuits in mouse brains
The mature brain is infamously bad at repairing itself following damage like that caused by trauma or strokes, or from degenerative diseases like Parkinson’s. Stem cells, which are endlessly adaptable, have offered the promise of better neural repair. But the brain’s precisely tuned complexity has stymied the development of clinical treatments.
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160 genes linked to brain shrinkage
A new study implicates 160 genes in brain shrinkage seen on MRIs of 45,000 healthy adults. The shrinkage is in the cortex, the dimply outer layer of the brain that gives rise to thinking, awareness and action, and largely consists of gray matter.
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Insomnia, sleeping less than six hours may increase risk of cognitive impairment
New research from Penn State College of Medicine may help health care professionals understand which patients who report insomnia are at increased risk for developing dementia. Middle-aged adults who report symptoms on insomnia and sleep less than six hours of asleep a night may be at increased risk of cognitive impairment.
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大脑内的果糖与阿兹海默症的发病有关
果糖是一种单糖，通常大量存在于水果中。但事实上，人脑也能制造果糖，且科罗拉多大学的一项研究指出，大脑内过度活跃的果糖代谢与阿兹海默症（AD）的发病具有直接联系。在将大脑内的大量葡萄糖转化成果糖的过程中，线粒体会出现供能不足的情况，从而导致脑组织无法维持正常功能。如果大脑长期处于果糖代谢过度活跃的状态，那么大脑内的氧化应激水平就会久高不下，最终导致脑细胞出现大面积死亡。这便解释了为何糖尿病和肥胖人群具有较高的阿兹海默症患病风险。该研究成果的确立为AD的防治指明了一条新的路径，只要对大脑内的果糖代谢进行干预，就有望能减缓AD的发病进程。