Author: Nick

  • TCCI®-affiliated Professor Wins NIH Director’s Pioneer Award

    TCCI®-affiliated Professor Wins NIH Director’s Pioneer Award

    Magdalena Zernicka-Goetz, Bren Professor of Biology and Biological Engineering is one of four Caltech faculty members to receive grants from the NIH’s High Risk, High Reward Research Program. Zernicka-Goetz, a TCCI®-affiliated faculty member, received a NIH Director’s Pioneer Award which “challenges investigators at all career levels to pursue new research directions and develop groundbreaking, high-impact […]

  • New clues about the link between stress and depression

    Researchers at Karolinska Institutet have identified a protein in the brain that is important both for the function of the mood-regulating substance serotonin and for the release of stress hormones, at least in mice. The findings, which are published in the journal Molecular Psychiatry, may have implications for the development of new drugs for depression […]

  • Neuroscientists discover a molecular mechanism that allows memories to form

    When the brain forms a memory of a new experience, neurons called engram cells encode the details of the memory and are later reactivated whenever we recall it. A new MIT study reveals that this process is controlled by large-scale remodeling of cells’ chromatin. This remodeling, which allows specific genes involved in storing memories to […]

  • Millimetre-precision drug delivery to the brain

    Focused ultrasound waves help ETH researchers to deliver drugs to the brain with pinpoint accuracy, in other words only to where their effect is desired. This method is set to enable treatment of psychiatric and neurological disorders and tumours with fewer side effects in the future.

  • NIH scientists reveal how the brain may fuel intense neural communication

    Our thoughts, feelings, and movements are controlled by billions of neurons talking to each other at trillions of specialized communication points called synapses. In an in-depth study of neurons grown in laboratory petri dishes, National Institutes of Health researchers discovered how the chattiest of some synapses find the energy to support intense conversations thought to […]

  • Stem cells can help repair spinal cord after injury

    Spinal cord injury often leads to permanent functional impairment. In a new study published in the journal Science researchers at Karolinska Institutet show that it is possible to stimulate stem cells in the mouse spinal cord to form large amounts of new oligodendrocytes, cells that are essential to the ability of neurons to transmit signals, […]

  • ‘Social cells’ related to social behavior identified in the brain

    A research team led by Professor TAKUMI Toru of Kobe University’s Graduate School of Medicine (also a Senior Visiting Scientist at RIKEN Center for Biosystems Dynamics Research) have identified ‘social cells’ in the brain that are related to social behavior. The cells were identified via Ca imaging (*1) conducted using a microendoscope (*2). It is […]

  • Penn Medicine Researchers Discover A Rare Genetic Form of Dementia

    A new, rare genetic form of dementia has been discovered by a team of Penn Medicine researchers. This discovery also sheds light on a new pathway that leads to protein build up in the brain — which causes this newly discovered disease, as well as related neurodegenerative diseases like Alzheimer’s Disease — that could be […]

  • How Aggression Leads to More Aggression

    How Aggression Leads to More Aggression

    Like a champion fighter gaining confidence after each win, a male mouse that prevails in several successive aggressive encounters against other male mice will become even more aggressive in future encounters. This phenomenon is interesting to scientists who study behavioral neuroscience because aggression is an innate behavior in the brain.  Now a team of Caltech […]

  • 研究确立了睡眠呼吸暂停综合征与阿兹海默症的关联

    虽然已有研究表明睡眠呼吸暂停综合征会增加阿兹海默症的患病风险,而阿兹海默症患者亦更容易在睡眠时出现呼吸骤停症状,但两者为何会具有这种关联性以及其中的生物学机制又是什么却仍不甚明了。在对呼吸暂停综合症患者的海马体以及脑干组织进行研究后,皇家墨尔本理工大学的团队发现,呼吸暂停综合症患者的脑内同阿兹海默症患者一样存在着大量的β-淀粉样蛋白和过度磷酸化的Tau蛋白,且这些有毒蛋白最开始出现的地方以及扩散模式也和阿兹海默症的发病特征一模一样。呼吸暂停综合症的症状越是严重,有毒蛋白的堆积量也就越大。在使用气道正压通气的方法对呼吸暂停综合征进行治疗后,这些有毒蛋白也不会随之减少。鉴于这些患者并未表现出任何认知方面的问题,研究人员推测,他们有很大的可能正处于老年痴呆症的早期阶段。在这之后,该团队还打算扩大样本,并对炎症反应以及脑血管的变化进行深入研究,以获取更多有关这两种疾病的病理学信息。