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Early signs of Alzheimer’s disease in people with Down’s syndrome
Researchers at Karolinska Institutet in Sweden have studied the incidence and regional distribution of Alzheimer’s disease biomarkers in the brains of people with Down’s syndrome. The results can bring new possibilities for earlier diagnosis and preventive treatment of dementia. The study is published in Molecular Neurodegeneration. In the current study, the researchers studied the extent […]
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Drug eases recovery for those with severe alcohol withdrawal
A drug once used to treat high blood pressure can help alcoholics with withdrawal symptoms reduce or eliminate their drinking, Yale University researchers report Nov. 19 in the American Journal of Psychiatry. In a double-blind study, researchers gave the drug prazosin or a placebo to 100 people entering outpatient treatment after being diagnosed with alcohol […]
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Taking Out the Trash is Essential for Brain Health
A research team at Tokyo Medical and Dental University (TMDU) find that Wipi3, a protein involved in cellular waste disposal, is crucial for neuronal health Tokyo, Japan – A little mess never killed anyone, right? Wrong. Researchers at Tokyo Medical and Dental University (TMDU) have recently shown that a build-up of cellular “trash” in the […]
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CLCN6 identified as disease gene for a severe form of lysosomal neurodegenerative disease
A mutation in the CLCN6 gene is associated with a novel, particularly severe neurodegenerative disorder. Scientists from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and the Max Delbrück Center für Molekulare Medizin (MDC), together with an international team of researchers, have now analyzed the effect of a point mutation that was found in three unrelated affected […]
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Diabetes increases neuritic damage around amyloid plaques in Alzheimer’s disease
New research from the University of Eastern Finland explores the role of diabetes in the cellular and molecular changes underlying Alzheimer’s disease (AD). In an AD mouse model, diabetes induced through a diet rich in fats and sugars weakened the accumulation of microglial cells around amyloid plaques and increased the formation of neuritic plaques with […]
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Tau protein changes correlate with Alzheimer’s disease dementia stage
Research into Alzheimer’s disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients’ brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain. In new research from their joint laboratory, Judith Steen, PhD, and Hanno […]
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New electronic chip delivers smarter, light-powered AI
Researchers have developed artificial intelligence technology that brings together imaging, processing, machine learning and memory in one electronic chip, powered by light. The prototype shrinks artificial intelligence technology by imitating the way that the human brain processes visual information. The nanoscale advance combines the core software needed to drive artificial intelligence with image-capturing hardware in […]
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The long road to dementia
Alzheimer’s disease develops over decades. It begins with a fatal chain reaction in which masses of misfolded beta-amyloid proteins are produced that in the end literally flood the brain. Researchers including Mathias Jucker from the Hertie Institute for Clinical Brain Research (HIH) in Tübingen and the German Center for Neurodegenerative Diseases (DZNE) show in the […]
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Researchers Improve Neuronal Reprogramming by Manipulating Mitochondria
The replacement of lost neurons is a holy grail for neuroscience. A new promising approach is the conversion of glial cells into new neurons. Improving the efficiency of this conversion or reprogramming after brain injury is an important step towards developing reliable regenerative medicine therapies. Researchers at Helmholtz Zentrum München and Ludwig Maximilians University Munich […]
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关于颜色的设想：大脑中的活动模式对于你看到的颜色来说是特定的
描述颜色之间关系的几何学，以及支持色觉的神经机制，目前尚未盖棺定论。这项研究使用脑磁图技术对大脑活动进行测量，并对测量结果进行多变量分析，对表达色彩空间的神经的几何结构进行逆向工程。这些分析取决于确定对不同颜色的神经反应的空间模式之间的相似关系，并评估这些关系如何随时间变化。我们将结果与颜色命名中的通用模式相关联，以此来评估该方法。通过解码结果，可以解释两种显着的颜色命名模式：与通过色相和明暗度的交互作用表现出的冷色相比，对暖色进行命名的精度更高，且在红色系中更为明显。额外的实验表明，对颜色词汇的响应进行训练的分类器可以从使用有色刺激获得的数据中解码颜色，但只能在刺激发生后较长的延迟内进行。这些结果佐证了，知觉表示可以产生语义表示，但反之则不成立。综上所述，该研究结果揭示了一种动态几何结构，该几何结构为颜色外观提供了神经相关性，并提出了有关颜色空间结构的新假设。